Q5(a) · UPSC Civil Services Mains 2023 · Anthropology GS 1 · 10 marks · 1 min read

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Polygenic Inheritance

Topic: Mendelian genetics in man-family study, single factor, multifactor, lethal, sub-lethal and polygenic inheritance in man.. Syllabus: 9.2 Mendelian genetics in man-family study, single factor, multifactor, lethal, sub-lethal and polygenic inheritance in man. Same official PYQ from year-wise 2023 and Mendelian genetics in man-family study, single factor, multifactor, lethal, sub-lethal and polygenic inheritance in man..

Revision summary

Polygenic traits are built by many loci of small effect. Fisher joined Mendelism to Galton’s continuous curves. Nilsson-Ehle’s wheat colour is the classic additive model. Human stature and skin colour are standard anthropological examples. GWAS still finds many tiny effects, not a racial master gene.

Model answer

Introduction

Polygenic inheritance is the passing of a trait that many loci of small effect build together. The result is a curve of people, not a 3:1 garden of peas.

Body

The genetic idea

  • R. A. Fisher showed that many Mendelian loci plus environment can produce the continuous distributions that Francis Galton had measured for stature.
  • Nilsson-Ehle’s wheat-kernel colour is the teaching plant model: add more contributing alleles and the colour darkens by steps that look smooth in a large sample.
  • Human stature, skin colour, blood pressure, and many disease risks sit in this architecture, which is why they are also called multifactorial when environment is counted.

Anthropological use

  • Skin colour is a polygenic cline with latitude and ultraviolet light, not a three-race switch, which is why Livingstone and later geneticists rejected racial typology for this trait.
  • Twin and family studies estimate heritability, but a heritability figure is not a gene list and is not destiny across environments.
  • Genome-wide association studies now name many loci of tiny effect, which confirms the old polygenic picture without restoring Mendelian race types.

Flow diagram

flowchart TD
  L[Many loci] --> Q[Quantitative trait]
  E[Environment] --> Q
  Q --> H[Height skin colour]

Conclusion

Polygenic inheritance is many small loci making a quantitative trait. Anthropology needs it for stature, pigmentation, and complex disease, and it forbids treating those traits as single-gene races.

Quick related

Students also ask

  • Prehistoric significance of Rakhigarhi

    Next question in the 2023 paper (Q5). View answer →

  • Is a polygenic trait non-Mendelian at each locus?

    Each locus can still segregate. The phenotype looks non-Mendelian because many loci and the environment are summed.

  • Can polygenic scores define races?

    No. They describe statistical risk or stature inside samples. They do not restore biological races.

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